In recent years, many doctors have been advocating 
                                  that women switch from synthetic hormones to 
                                  natural hormones. In this issue, Dr. Helen Pensanti 
                                  warns of the medical risks of synthetic hormone 
                                  therapy. 
                    
                       
                        | 1. | 
                        Premarin 
                          is not "natural" to the human body. It is 
                          made from pregnant mares urine. The generic name for 
                          Premarin is conjugated equine estrogen. | 
                      
                       
                        | 2. | 
                        In 
                          1995, The American Journal of Obstetrics and Gynecology 
                          published an article stating that not only long-term, 
                          but short-term use of Premarin had a 40% percent risk 
                          of acquiring breast cancer!  | 
                      
                       
                        | 3. | 
                        1995 
                          Nurses' Health Study (one of the largest studies done 
                          to date): Women taking synthetic estrogen alone had 
                          a 36% increase in risk of breast cancer; those on synthetic 
                          estrogen plus progestin had a 50% increase; those on 
                          progestins alone had a 240% increase of breast cancer. 
                          Women who, at the time of the study, had been taking 
                          estrogen and progestin for 5-10 years had a 45% increase 
                          in their risk of breast cancer.  | 
                      
                       
                        | 4. | 
                        1995 
                          Nurses' Health Study: the older a woman was, the higher 
                          the risk. Women between the ages of 60 and 64 who had 
                          been taking synthetic hormones for five years or more 
                          had a 71% increased risk of developing breast cancer. 
                           | 
                      
                       
                        | 5. | 
                        Mainstream 
                          medical doctors use the rationale that elevated cancer 
                          risks are balanced by the fact that these estrogens 
                          protect against heart disease and osteoporosis. In April 
                          2000, a federal study of 25,000 women published in the 
                          New York Times indicated that conventional hormone replacement 
                          therapy may put women at a higher risk of heart attack 
                          and stroke.  | 
                      
                       
                        | 6. | 
                        The 
                          estrogen, "estriol" is completely missing 
                          from some forms of conventional hormone replacement 
                          therapy. In the female human body, estriol is the estrogen 
                          that is found in the greatest amount compared to estrone 
                          and estradiol. Over 80% of this natural tri-estrogen 
                          is estriol in females. Studies have shown that estriol 
                          protects the body from the more carcinogenic estrone 
                          and estradiol and is especially protective against breast 
                          cancer!  | 
                      
                       
                        | 7. | 
                        The 
                          percentages of estrone and estradiol found in Premarin 
                          are much greater than the levels your body produces 
                          naturally. This leads to hormone imbalance. | 
                      
                       
                        | 8. | 
                        The 
                          "patch" contains 100% estradiol which is the 
                          most potent of all the estrogens found in the female 
                          body, It contains no estrone and no estriol. If you 
                          look in the Physician's Desk Reference under listing 
                          for the patch which is sold under several brand names, 
                          you will see, in large print, the following statement: 
                          ESTROGENS HAVE BEEN REPORTED TO INCREASE THE RISK OF 
                          ENDOMETRIAL CARCINOMA IN POSTMENOPAUSAL WOMEN.  | 
                      
                       
                        | 9. | 
                        2000 
                          Physician's Desk Reference (PDR): Side effects of Premarin: 
                          Endometrial cancer, breast cancer, blood clots, uterine 
                          bleeding, uterine fibroids, weight gain, mental depression, 
                          edema, changes in libido, gallbladder disease.  | 
                      
                       
                        | 10. | 
                        A 
                          side effect of synthetic hormones is weight gain, especially 
                          around the middle, hips, and thighs (the classic "pear- 
                          shaped" weight gain). The average weight gain I 
                          saw in women who were placed on synthetic hormones was 
                          between 20-30 pounds, sometimes even more!  |